Medication Explained


Disclaimer:

This website is intended to assist with patient education and should not be used as a diagnostic, treatment or prescription service, forum or platform. Always consult your own healthcare practitioner for a more personalised and detailed opinion


Raloxifene

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

 

Popular brand names:

Evista

Drug group:

Drug for bone disorders

Prescription needed?

Yes

 

What does it do?

  • Raloxifene is prescribed to prevent vertebral fractures in postmenopausal women who are at risk of osteoporosis
  • There is some evidence that it would also be useful for preventing fractures of the hip, but not other bones
  • Raloxifene has no beneficial effect on other menopausal problems such as hot flushes

 

How does it work?

  • Raloxifene is a selective oestrogen receptor modulator
  • It binds to oestrogen receptors and inhibits bone resorption, without stimulating the endometrium or breast tissue

 

How should it be used?

Calcium supplements are recommended if dietary calcium is low

 

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

60mg once daily

 

How quickly will it start to work?

1–4 hours        
                   

How long will the effects last?

24–48 hours                  
          

When should I stop using it?

Do not stop without consulting your doctor.

To avoid blood clots, raloxifene will be stopped if you become immobile or bedbound, and restarted when full activity is resumed.      
                            

Is it safe for prolonged use?

Raloxifene is usually used long term. Benefit has to be weighed against the increased risk of stroke and venous thrombosis. Liver function tests may be done regularly.

                                                                         

What are the possible side effects?

The following have been reported:

  • More common: hot flushes, leg cramps, swollen ankles/feet, flu-like symptoms
  • Less common: headaches
  • Report to your doctor before taking your next dose if you experience: rash, signs of thrombosis or blood clot in the leg (pain/tenderness/swelling/discoloration/ulceration)

 

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

  • Certain health problems: liver/kidney problems, history of a blood clot or pulmonary embolism, postmenopausal vaginal bleeding
  • Other medicines: anticoagulants, colestyramine
  • Pregnancy and breast-feeding: Not prescribed to pre-menopausal women
  • Children: Not prescribed
  • Over 60: No special problems
  • Driving and hazardous work: No special problems
  • Alcohol: No special problems