Bezafibrate

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Bezachole SR, Bezalip, Dyna Bezafibrate 400 SR

Drug group:

Lipid-lowering drug

Prescription needed?

Yes

What does it do?

Bezafibrate prevents deposition of fat in blood vessel walls (atherosclerosis), reducing the risk of coronary artery disease (eg heart attacks) and cerebrovascular disease (eg stroke).

How does it work?

• Bezafibrate is a lipid lowering drug from the group called fibrates
• Fibrates decrease levels of cholesterol and triglycerides in the blood stream

How should it be used?

• The combination of bezafibrate with statins should be used with caution due to the increased risk of muscle damage
• A low-fat diet can help to reduce blood lipid levels
• Tablets should be taken with a little liquid after a meal

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

400–600mg daily, taken 1–3 x daily

How quickly will it start to work?

Blood fat levels may reduce in a few weeks, fat deposits in the arteries are reduced in months or years.

How long will the effects last?

About 6–24 hours

When should I stop using it?

Discuss with your doctor. If lipid levels have not decreased within 3–4 months, your doctor might try alternative treatment.

Is it safe for prolonged use?

No problems expected, but there is a higher risk of muscle damage in patients with kidney problems. Regular monitoring may be required.

What are the possible side effects?

The following have been reported:

• More common: loss of appetite, nausea, stomach pain
• Less common: dizziness, fatigue
• Report to your doctor before taking your next dose if you experience: rash, headache, muscle pain, cramps, weakness

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/gallbladder/kidney problems
• Other medicines: Anticoagulants (eg warfarin), monoamine oxidase inhibitors (MAOIs), antidiabetic agents, statins, ciclosporin
• Pregnancy and breast-feeding: Safety not established
• Children: Not usually prescribed
• Over 60: No special problems expected
• Driving and hazardous work: Caution, the drug can cause dizziness
• Alcohol: No special problems