Digoxin

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Lanoxin, Purgoxin

Drug group:

Digitalis drug

Prescription needed?

Yes

What does it do?

Digoxin is used in the treatment of:

• Irregular heart rhythms - such as atrial fibrillation or atrial flutter
• Congestive heart failure – can help to control breathlessness, fluid retention, and tiredness

How does it work?

• Digitalis is a compound obtained from the leaves of the foxglove plant
• Digoxin increases the force of the heartbeat, making it more effective in pumping blood around the body

How should it be used?

• Avoid low potassium levels as this increases digitalis toxicity - eat potassium-rich foods
• Many drugs interact with digoxin, always check with your doctor or pharmacist

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

• Initially up to 3 x daily, then once daily as maintenance
• Usually 0.0625–0.25mg by mouth daily, but doses of up to 0.5mg are occasionally used
• The effective dose of digoxin can be close to the toxic dose so careful monitoring is needed

How quickly will it start to work?

Injection within a few minutes; by mouth within 1–2 hours

How long will the effects last?

Up to 4 days
           

When should I stop using it?

Do not stop taking digitalis without discussing with your doctor.
       

Is it safe for prolonged use?

No problems expected, but blood levels of digoxin and electrolytes should be monitored.

What are the possible side effects?

ALL adverse effects should be reported as they are usually due to high levels of digoxin in the blood.

The following have been reported:

• More common: tiredness, nausea, loss of appetite
• Less common: confusion, visual disturbance, palpitations
• Report to your doctor before taking your next dose if you experience: palpitations and/or visual disturbances

OVERDOSE ACTION 

Seek immediate medical care!

Large overdoses can cause palpitations, severe weakness, chest pain, or loss of consciousness.

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: heart rhythm problems, kidney/thyroid problems
• Other medicines: Diuretics, ciclosporin, tacrolimus, calcium channel blockers, anti-arrhythmic drugs (e.g. amiodarone and quinidine), antacids
• Pregnancy and breast-feeding: No evidence of risk at normal doses
• Children: Reduced dose necessary
• Over 60: Reduced dose may be necessary
• Driving and hazardous work: Caution, digoxin can cause tiredness and visual disturbances
• Alcohol: No special problems