Dipyridamole

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Persantin, Persantin Retard

Popular combinations:

Asasantin Retard

Drug group:

Antiplatelet drug

Prescription needed?

Yes

What does it do?

Dipyridamole reduces the risk of clotting in people who:

• Have had a stroke or transient ischaemic attacks (TIAs)
• Have undergone heart valve replacement surgery

Dipyridamole is usually given with other drugs such as warfarin or aspirin.

How does it work?

Dipyridamole reduces the ability of platelets to stick to each other and to blood vessel walls, which reduces the likelihood of clot formation.

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

• Tablets/capsules/liquid: 300–600mg daily, in 3–4 divided doses, taken 1 hour before meals
• MR capsules: 400mg daily, taken in 2 x divided doses, with food

How quickly will it start to work?

Within 1 hour, full therapeutic effect 2–3 weeks
               

How long will the effects last?

Up to 8 hours (MR capsules 12 hours)

When should I stop using it?

Do not stop taking the drug without consulting your doctor.
               

Is it safe for prolonged use?

No known problems.

What are the possible side effects?

Side effects with dipyridamole are rare.


The following have been reported:

• Less common: nausea, cramps, diarrhoea, headache, flushing, worsening angina, bleeding
• Report to your doctor before taking your next dose if you experience: dizziness/fainting, rash, breathing difficulties, swollen lips

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: low blood pressure, blood clotting disorders, migraines, angina, heart valve problems, recent heart attack, myasthenia gravis
• Other medicines: Anticoagulant drugs, adenosine, antihypertensives, cholinesterase inhibitors, antacids
• Pregnancy and breast-feeding: Safety in pregnancy not established, adverse effects on the breastfed baby are unlikely at normal doses
• Children: Reduced dose necessary
• Over 60: No special problems
• Driving and hazardous work: Caution, the drug may cause dizziness and faintness
• Alcohol: Avoid, increased risk of dizziness and faintness