Glibenclamide

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Bio glibenclamide, Diacare, Glycomin

Popular combinations:

Glucovance

Drug group:

Drug for diabetes

Prescription needed?

Yes

What does it do?

Glibenclamide is used in the treatment of Type 2 diabetes

How does it work?

• Glibenclamide is an oral antidiabetic drug belonging to the sulphonylurea class
• It stimulates the production and secretion of insulin from the islet cells in the pancreas
• Insulin increases the uptake of sugar into body cells, which decreases blood sugar levels

How should it be used?

• Medication forms only part of diabetes treatment, exercise and correct diet are essential
• Take missed dose with your next meal, do not double-dose to make up for the missed one
• If you experience early warning symptoms of low blood sugar, eat or drink something sugary

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

Total adult daily dose: 5–15mg, taken once daily in the morning with breakfast

How quickly will it start to work?

Within 3 hours      
                            

How long will the effects last?

10–15 hours          

When should I stop using it?

Do not stop the drug without consulting your doctor  
                               

Is it safe for prolonged use?

No problems expected. All diabetics need regular blood tests for sugar levels and kidney function, as well as eye assessments, heart examinations, and urine tests.

What are the possible side effects?

The following have been reported:

• More common: dizziness, fainting, weakness, sweating, trembling, confusion, or headache (symptoms of hypoglycaemia or low blood sugar - usually due to missed meals)
• Less common: constipation, diarrhoea, nausea, vomiting, rash, itching, weight changes
• Report to your doctor before taking your next dose if you experience: jaundice

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/kidney/thyroid/adrenal problems, allergy to sulphonylurea drugs, porphyria
• Other medicines: corticosteroids, oestrogens, diuretics, rifampicin, warfarin, aspirin, sulphonamides and other antibacterials, antifungals, NSAIDs, ACE inhibitors, beta blockers
• Pregnancy and breast-feeding: Not usually prescribed
• Children: Not prescribed
• Over 60: Reduced doses may be necessary
• Driving and hazardous work: Usually no problems, unless symptoms of low blood sugar
• Alcohol: Avoid, alcohol may upset diabetic control
• Surgery and general anaesthetics: Always notify your doctor that you have diabetes
• Sunlight: Avoid too much exposure, the drug may make your skin more sensitive