Simvastatin

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Simvacor, Zocor

Popular combinations:

Inegy

Drug group:

Lipid-lowering drug

Prescription needed?

Yes (except low-dose preparations)

What does it do?

Simvastatin is prescribed for people with hypercholesterolaemia (high blood cholesterol):

• Who have not responded to other interventions including diet
• Who already have or are at risk of developing coronary heart disease or stroke

How does it work?

Simvastatin blocks the action of an enzyme needed for the production of cholesterol in the liver, resulting in lowered blood levels of cholesterol.

How should it be used?

• Following a low-fat diet is helpful in reducing blood cholesterol levels
• Do not drink grapefruit juice regularly as it increases blood levels of simvastatin

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

10–80mg once daily, usually at night

How quickly will it start to work?

Some effect within 2 weeks, full beneficial effects 4–6 weeks.     

How long will the effects last?

Up to 24 hours          
             

When should I stop using it?

Do not stop taking the drug without consulting your doctor.        
          

Is it safe for prolonged use?

Long-term use can adversely affect the liver. You may need regular blood tests to monitor liver function and check for muscle toxicity.

What are the possible side effects?

Side effects are usually mild and wear off with time.

The following have been reported:

• More common: abdominal pain, constipation/diarrhoea, nausea, flatulence, sleep disturbance, headache
• Less common: raised liver enzymes, muscle damage
• Report to your doctor before taking your next dose if you experience: rash, jaundice, muscle pain/tenderness/weakness

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/kidney problems, personal/family history of muscle problems, porphyria
• Other medicines: ciclosporin, danazol, fibrates, nicotinic acid, amiodarone, verapamil, diltiazem, itraconazole, ketoconazole, HIV protease inhibitors, macrolide antibiotics, nefazodone, St John’s wort, anticoagulants (e.g. warfarin), carbamazepine
• Pregnancy and breast-feeding: Not recommended, may affect fetal development and the breastfed baby
• Children: Not recommended under 5 years, reduced dose necessary in older children
• Over 60: No special problems
• Driving and hazardous work: No special problems
• Alcohol: Avoid excessive amounts, increased risk of liver problems