Pregabalin

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Lyrica

Drug type:

Anti-epileptic, Analgesic drug

Prescription needed?

Yes

What does it do?

Pregabalin is used in the treatment of neuropathic pain (pain caused by damage to the nerves):

• Post-herpetic neuralgia (the pain associated with shingles)
• Diabetic neuropathy (a painful complication of diabetes)

How does it work?

Pregabalin is thought to work by calming overactive damaged nerves, but the exact mechanism of action is unknown

How should it be used?

• Pregabalin can be taken with or without food
• Capsules should be swallowed whole with water

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

• Adults: initially 75mg taken twice daily
• Dose can be increased if necessary after 3-7 days to 150mg twice daily

How quickly will it start to work?

Effects can be felt after about 1 week.   

How long will the effects last?

12 hours.                 

When should I stop using it?

Do not stop the drug without consulting your doctor.

The drug should be withdrawn over a period of at least 1 week.

Is it safe for prolonged use?

Long-term use increases the risk and severity of withdrawal symptoms when stopping the drug (headache, insomnia, anxiety, agitation). However, these symptoms may also occur after short-term use.

You will need regular blood tests to monitor liver/kidney function and blood cell counts.                   

What are the possible side effects?

The following have been reported:

• More common: dizziness, somnolence/sleepiness, headache, memory and concentration problems, irritability, tremor, vertigo, blurred/double vision
• Less common: rapid pulse, hot flushes, muscle/joint pains, sexual dysfunction, decreased urination, low/high blood sugar
• Report to your doctor before taking your next dose if you experience: rash, red/blistering skin, shortness of breath, swelling of the face/lips, severe abdominal pain, severe muscle pain, confusion, seizures, loss of consciousness

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/kidney/heart problems, current or planned pregnancy, lactose intolerance
• Other medicines: sedatives, oxycodone, lorazepam
• Pregnancy and breast-feeding: Safety not established, use not recommended
• Children: Safety not established in patients <18 years
• Over 60: Reduced doses may be necessary
• Driving and hazardous work: Caution, the drug may cause dizziness and somnolence
• Alcohol: Avoid, increased dizziness and problems with concentration