Amiloride

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular combinations:

Adco-retic, Amiloretic, Moduretic

Drug type:

Potassium-sparing diuretic

Prescription needed:

Yes

What does it do?

Amiloride is a mild diuretic used in the treatment of:

• Oedema (fluid retention)
• Hypertension (high blood pressure)

How does it work?

• Amiloride acts on the kidneys to increase the amount of urine that is passed
• It causes the kidneys to conserve potassium
• It is often combined with other diuretics

How should it be used?

• Take in the morning to avoid high urine volumes at night
• Avoid foods that are high in potassium

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

• Adults total 5–20mg per day, taken once or twice daily

When will it start to work?  

Within 2–4 hours

How long will the effects last?  

About 12 hours

When should I stop using it? 

Use as directed by your doctor

Is it safe for prolonged use? 

Yes, but your doctor may do regular blood tests for kidney function

What are the possible side effects?

The following have been reported:

• More common: muscle weakness or heart rhythm problems (caused by potassium/sodium imbalance)
• Less common: digestive disturbance, confusion, muscle cramps, dry mouth, thirst, dizziness
• Report to your doctor before taking your next dose if you experience: rash

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/kidney problems, high blood potassium levels
• Other medicines: Lithium, ACE inhibitors, angiotensin II blockers, renin inhibitors (e.g. aliskiren), ciclosporin, drosperinone, tacrolimus, and NSAIDs
• Pregnancy and breast-feeding: Not usually prescribed
• Children: Not recommended
• Over 60: Reduced doses may be necessary, higher risk of side effects
• Driving and hazardous work: No known problems
• Alcohol: No special problems