Levetiracetam

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names:

Epikepp, Keppra, Redilev

Drug group:

Anticonvulsant drug

Prescription needed?

Yes

What does it do?

• Levetiracetam is used in the treatment of some forms of epilepsy
• It is either used alone or in combination with other anti-epileptic drugs
• Levetiracetam does not interact with other anti-epileptic drugs, and it has less side effects

How does it work?

• Levetiracetam reduces the likelihood of seizures caused by abnormal nerve signals in the brain
• It is chemically different from other anti-epileptic drugs, but the exact way in which it works is not fully understood

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

• Initially 250mg once daily, then increased after 1–2 weeks to 250mg twice daily
• If necessary the dose can be further increased up to a maximum of 1.5g twice daily

How quickly will it start to work?

Within 48 hours                     
          

How long will the effects last?

12 hours                  

When should I stop using it?

Do not stop the drug without consulting your doctor.       
                          

Is it safe for prolonged use?

Usually no problems, but it can very rarely cause depression and suicidal thoughts.                                                           

What are the possible side effects?

Levetiracetam causes few side effects.

The following have been reported:

• More common: headache, dizziness, drowsiness, gastrointestinal disturbances (such as nausea, vomiting, indigestion and abdominal pain), and a cough
• Report to your doctor before taking your next dose if you experience: itching, rash, mood changes, depression, suicidal thoughts

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/kidney problems, psychotic or depressive illnesses
• Other medicines: antidepressants (MAOIs, tricyclics and SSRIs), mefloquine, St John’s wort
• Pregnancy and breast-feeding: Safety not established
• Children: Reduced dose necessary
• Over 60: No special problems
• Driving and hazardous work: Caution, the drug can cause drowsiness
• Alcohol: Avoid, added sedative effect