Diltiazem

Please note: these are basic guidelines, refer to your doctor for a professional medical opinion.

Popular brand names: 

Adco-Zildem, Sandoz Diltiazem

Drug group:

Calcium channel blocker, antihypertensive drug

Prescription needed?

Yes

What does it do?

Diltiazem is used in the treatment of:

• Angina – can be taken regularly to reduce the frequency of angina attacks, but it does not work quickly enough to reduce the pain of an angina attack that has already started
• High blood pressure - longer acting formulations used

How does it work?

Diltiazem is a calcium channel blocker - it interferes with the conduction of signals in the muscles of the heart and blood vessels.

How should it be used?

You should always use the same brand of sustained-release (SR) diltiazem as different brands may not be equivalent

What is the typical dosage?

Your doctor will recommend a dosage tailored to your need, but typically:

• Adults 180–480mg daily
• Tablets/capsules taken 3 x daily; SR tablets/SR capsules taken 1–2 x daily

How quickly will it start to work?

2–3 hours
                            

How long will the effects last?

6–8 hours
                

When should I stop using it? 

Do not stop taking the drug without consulting your doctor, stopping suddenly may worsen angina.
 

Is it safe for prolonged use?

No problems expected.                                                                 

What are the possible side effects?

Diltiazem can cause various minor side effects.

The following have been reported:

• More common: headache, nausea, vomiting, dry mouth, ankle swelling
• Less common: breast/gum enlargement, slow heart rate, dizziness, tiredness
• Report to your doctor before taking your next dose if you experience: rash

Diltiazem does not adversely affect breathing and is therefore useful in people with asthma (where other anti-angina drugs may not be suitable).

What other considerations are important?

Dosage may be adjusted by your doctor under certain conditions.

• Certain health problems: liver/kidney problems, heart failure
• Other medicines: antihypertensive drugs, anticonvulsant drugs, anti-arrhythmic drugs, beta blockers, digoxin, simvastatin, theophylline/aminophylline
• Pregnancy and breast-feeding: Not usually prescribed in pregnancy, may affect the breastfed baby
• Children: Not recommended
• Over 60: Reduced doses may be necessary, increased risk of side effects
• Driving and hazardous work: Caution, the drug can cause dizziness
• Alcohol: Avoid excessive amounts, alcohol may lower blood pressure, causing dizziness